Sex differences in the impact of resistance exercise load on muscle damage: A protocol for a randomised parallel group trial.

Sex differences in the impact of resistance exercise load on muscle damage: A protocol for a randomised parallel group trial.

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IntroductionResistance training can induce skeletal muscle hypertrophy and strength gains, but is also associated with acute muscle damage, characterised hp 14a-na0031wm by muscle soreness, impaired muscle function, and structural damage to muscle cell membranes and its components.These consequences can be detrimental to future exercise performance and dampen long-term training adaptations.Previous research has considered resistance exercise intensity as a factor in exercise-induced muscle damage (EIMD), though a clear direction of the findings has not yet been established.Further, female populations are heavily underrepresented in this field of study.Therefore, we here propose a study protocol designed to examine sex differences in the muscle damage response to resistance exercise performed with low or high loads in a population of untrained, young adults.

MethodsThis study will employ a randomised parallel group design.Twenty-four males and 24 females will perform an acute leg-based resistance exercise session at either 30% (low-load) or 80% (high-load) of their pre-determined one-repetition maximum (1RM).Maximal leg strength will be determined by a 1RM test 3 wk before and 72 and 168 h after the exercise bout.Additionally, muscle damage will be assessed immediately before the exercise bout and immediately, 24, 48, 72, and 168 h 12n/1200 wella after the exercise bout through measures of muscle soreness, limb circumference, range of motion, and serum concentrations of creatine kinase and interleukin-6.The outcomes of this trial could inform sex-specific resistance training recommendations and help bridge the sex data gap in sport and exercise science research.